Lisa K. Ryan, PhD

Infectious Diseases/Global Medicine, Lisa Kathleen Ryan, Ph.D.

Lisa Kathleen Ryan, PhD
Assistant Professor of Medicine

TEL:  (352) 273-8830
CELL: (973) 715-0516
FAX:  (352) 273-8829








Ph.D. University of Pittsburgh Toxicology
M.S. West Virginia University Medical School Medical Microbiology
B.S. Penn State University Microbiology
Postdoctoral Fellowship Harvard Medical School/Mass General Hospital Pulmonary Immunology

Academic/Research Interests

  • Beta-defensin involvement in the innate immunity against viruses
  • Defensin Peptide Mimetics
  •  Pathogenesis and innate immunity to influenza virus using a mouse animal model (H1N1 and H3N2)
  • Effect of particulate matter air pollution containing vanadium pentoxide on innate immune responses against lung infections in the airway epithelium
  • Pulmonary and tumor immunology


  • Ryan LK, Freeman KB, Masso-Silva JA, Aloyouny A, Markowitz K, Hise AG, Scott RW, Diamond G (2014) Activity of potent and selective host defense peptide mimetics in mouse models of oral candidiasis. Antimicrob Agents Chemother Apr 21 [Epub ahead of print] PMID: 24752272
  • Miller VM, Bucher C, Zhu Y, McGuiness WM, Ryan LK, Siegel A, Zalcman S (2013) Gestational flu  exposure induces neurochemical, hormonal, brainstem inflammatory changes and autism-like behaviors in mice.  Brain, Behav Immun 33:153-163.  PMID: 23880236
  • Ryan LK (2013) Vanadium Pentoxide effects on lungs. In Uversky V, Kretsinger RH, and Permyakov EA (eds.), Encyclopedia of Metalloproteins. Springer, New York, NY, pp.  2324- 2330.
  • Rigo I, McMahon L, Dhawan P, Christakos S, Yim S, Ryan LK, Diamond G (2012) Induction of triggering receptor expressed on myeloid cells (TREM-1) in airway epithelial cells by 1,25(OH)2 vitamin D3.  Innate Immun 18:250-257 PMI: 21690199
  • Ryan LK, Dai J, Yin Z, Megjugorac N, Uhlhorn V, Yim S, Schwartz KD, Abrahams JM, Diamond G, Fitzgerald-Bocarsly P (2011) Modulation of human beta-defensin-1 (hBD-1) in plasmacytoid dendritic cells (PDC), monocytes, and epithelial cells by influenza virus, Herpes simplex virus, and Sendai virus and its possible role in innate immunity. J Leukoc Biol 90: 343-356. PMI: 21551252
  • McMahon L, Schwartz K, Yilmaz O, Brown E, Ryan LK, Diamond G (2011) Vitamin D-mediated induction of innate immunity in gingival epithelial cells. Infect Immun 79: 2250-2256. PMI: 21422187
  • Diamond G, Ryan LK (2011) Beta-Defensins: What are they REALLY doing in the oral cavity? Oral Diseases 17: 628-635. PMI: 21332602
  • Diamond G, Beckloff N, Ryan LK (2008) Host defense peptides in the oral cavity and the lung: similarities and differences. J Dent Res 87: 915-927. PMI: 18809744
    Laube DM, Yim S, Ryan LK, Kisich KO, Diamond G (2006) Antimicrobial peptides in the airway. Curr Top Microbiol Immunol 306: 153-182. PMI: 16909921
  • Klein-Patel ME, Diamond G, Boniotto M, Saad S, Ryan LK (2006) Inhibition of beta-defensin gene expression in airway epithelial cells by low doses of residual oil fly ash is mediated by vanadium. Toxicol Sci 92: 115-125. PMI: 16641320
  • Ryan LK, Diamond G, Amrute S, Feng Z, Weinberg A, Fitzgerald-Bocarsly P (2003) Detection of HBD1 peptide in peripheral blood mononuclear cell subpopulations by intracellular flow cytometry. Peptides 24: 1785-1794. PMI: 15019211
  • Ryan LK, Copeland LR, Daniels MJ, Costa ER, Selgrade MJ (2002) Proinflammatory and Th1 cytokine alterations following ultraviolet radiation enhancement of disease due to influenza infection in mice. Toxicol Sci 67: 88-97. PMI: 11961220
  • Suliman HB, Ryan LK, Bishop L, Folz RJ (2001) Prevention of influenza-induced lung injury in mice overexpressing extracellular superoxide dismutase. Am J Physiol Lung Cell Mol Physiol 280: L69-78. PMI: 11133496
  • Ryan LK, Neldon DL, Bishop LR, Gilmour MI, Daniels MJ, Sailstad DM, Selgrade MJ (2000) Exposure to ultraviolet radiation enhances mortality and pathology associated with influenza virus infection in mice. Photochem Photobiol 72: 497-507. PMI: 11045721
  • Ryan LK (2000) Ozone. In Cohen M, Zelikoff J, and Schlesinger R (eds.), Pulmonary Immunotoxicology. Kluwer Publishing, New York, NY, pp. 301-336.
  • Diamond G, Legarda D, Ryan LK (2000) The innate immune response of the respiratory epithelium. Immunol Rev 173: 27-38. PMI: 10719665
  • Ryan LK, Rhodes J, Bhat M, Diamond G (1998) Expression of beta-defensin genes in bovine alveolar macrophages. Infect Immun 66: 878-881. PMI: 9453661
  • Ryan LK, Golenbock DT, Wu J, Vermeulen MW (1997) Characterization of proinflammatory cytokine production and CD14 expression by murine alveolar macrophage cell lines. In Vitro Cell Dev Biol Anim 33: 647-653. PMI: 9338148
  • Ryan LK, Vermeulen MW (1995) Alveolar macrophages from C3H/HeJ mice show sensitivity to endotoxin. Am J Respir Cell Mol Biol 12: 540-546. PMI: 7742017
  • Ryan LK, Jin R, Boggs SS, Karol MH, Day BW (1994) Mouse Model for Assessing Endotoxin Involvement in the Lung Inflammation and Cytokine Production Resulting from Inhaled Organic Dust. Inhal. Toxicol. 6: 485-499. PMI: 0
  • Ryan LK, Jin R, Boggs SS, Karol MH, Day BW (1993) Endotoxin involvement in cotton dust inflammation assessed using a murine model. In Jacobs RR et al. (ed.), Proceedings of the Seventeenth Cotton Dust Research Conference, New Orleans, LA. National Cotton Council, Memphis, TN, pp. 319-321.
  • Ryan LK, Karol MH (1991) Release of tumor necrosis factor in guinea pigs upon acute inhalation of cotton dust. Am J Respir Cell Mol Biol 5: 93-98. PMI: 1878256
  • Griffiths-Johnson DA, Ryan LK, Karol MH (1991) Development of an Animal Model for Organic Dust Toxic Syndrome. Inhal Toxicol 3: 405-417. PMI: 0
  • Ryan LK, Karol MH (1990) The effect of cotton dust exposure on the release of tumor necrosis factor from guinea pig alveolar macrophages. In Jacobs RR et al. (ed.), Proceedings of the Fourteenth Cotton Dust Research Conference, Las Vegas, NV. National Cotton Council, Memphis, TN, pp. 146-149. PMI:0
  • Ryan LK, Karol MH (1989) Acute respiratory response of guinea pigs to lipopolysaccharide, lipid A, and monophosphoryl lipid A from Salmonella minnesota. Am Rev Respir Dis 140: 1429-1435. PMI: 2817607
  • Griffiths-Johnson D, Ryan LK, Spear K, Karol MH (1989) Pulmonary response of guinea pigs to a chemically-treated crude preparation of E. agglomerans cells.  In Jacobs RR et al. (ed.), Proceedings of the Thirteenth Cotton Dust Research Conference, Nashville, TN. National Cotton Council, Memphis, TN, pp. 146-149. PMI:0
  • Ryan LK, Karol MH (1988) Production of antibody to lipopolysaccharide (LPS) after immunization with a LPS-polymyxin B-agarose immunogen. J Appl Bacteriol 64: 487-495. PMI: 3049507
  • Ryan LK, Erdal S, Karol MH (1988) Acute respiratory response of guinea pigs to lipopolysaccharide from Salmonella minnesota and the Re595 mutant.  In Jacobs RR et al. (ed.), Proceedings of the Twelfth Cotton Dust Research Conference, New Orleans, LA. National Cotton Council, Memphis, TN, pp. 47-49. PMI:0
  • Lange JH, Weyel DA, Rosato LM, Tucker D, Malek DE, Mayernik JA, Ryan LK (1987) Preliminary results on smoking patterns for workers attending an asbestos abatement course. Scand J Work Environ Health 13: 459. PMI: 3433048
  • Ryan LK, Karol MH (1987) Immune response to a lipopolysaccharide-polymyxin B complex. In Jacobs RR et al. (ed.), Proceedings of the Eleventh Cotton Dust Research Conference, Dallas, TX. National Cotton Council, Memphis, TN, pp. 47-49. PMI:0