Tuberculosis Epidemiologic Studies Consortium (TBESC)

Study Team

Study Summary

  • The “Prospective Comparison of the Tuberculin Skin Test and Interferon-Gamma Release Assays in Diagnosing Infection with Mycobacterium tuberculosis and in Predicting Progression to Tuberculosis” study is conducted by the Centers for Disease Control and Prevention (CDC) Division of Tuberculosis Elimination, as part of the Tuberculosis Epidemiologic Studies Consortium (TBESC). The study is being conducted at 10 TBESC sites within the United States. In Florida, the study is being conducted by the University of Florida Division of Infectious Diseases and Global Medicine in collaboration with the Florida Department of Health in Alachua and Miami-Dade Counties.
  • This is a prospective cohort study of persons tested for latent tuberculosis infection (LTBI) who are at either high risk for exposure to M. Tuberculosis or high risk for progression to TB disease. The study will assess the relative performance and cost of three diagnostic tests for LTBI (Tuberculin Skin Test (TST), QuantiFERON – TB Gold In-Tube test (QFT), and T-SPOT.TB test) and will examine the rates of positive results among the cohort. The study will also determine the risk and rate of progression to active TB disease, overall and by the results of the three tests.
  • For more information about eligibility criteria and participation in the study, please email Joanne at