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Frederick S. Southwick, MD

Infectious DiseaseFrederick S. Southwick, MD
Professor of Medicine


TEL: (352) 273-9511
FAX: (352) 273-6481








MD Columbia University College of Physicians and Surgeons
Residency Massachusetts General Hospital Internal Medicine
Fellowship Massachusetts General Hospital Infectious Disease

Academic/Research Interests:

  • Effect of Anthrax toxins on the Immune System
  • Effect of Anthrax toxins on the Immune System
  • Research on Improving the Quality and Safety of Patient Care


Bacillus anthracis’ Lethal Toxin Induces Broad Transcriptional Responses in Human Peripheral Monocytes. Chauncey KM, Lopez MC, Sidhu G, Szarowicz SE, Baker HV, Quinn C, Southwick FS. BMC Immunol. 2012 Jul 2;13(1):33.

Anthrax lethal and edema toxins fail to directly impair human platelet function. Chauncey KM, Szarowicz SE, Sidhu GS, During RL, Southwick FS. J Infect Dis. 2012 Feb 1;205(3):453-7.

Brucella, voles, and emerging pathogens. Morris JG Jr, Southwick FS. J Infect Dis. 2010 Jul 1;202(1):1-2.

Commentary: “Who was caring for Mary?” revisited: a call for all academic physicians caring for patients to focus on systems and quality improvement. Southwick FS, Spear SJ. Acad Med. 2009 Dec;84(12):1648-50.

Bacillus anthracis edema toxin impairs neutrophil actin-based motility. Szarowicz SE, During RL, Li W, Quinn CP, Tang WJ, Southwick FS. Infect Immun. 2009 Jun;77(6):2455-64.

Theodore E. Woodward Award: spare me the PowerPoint and bring back the medical textbook. Southwick FS. Trans Am Clin Climatol Assoc. 2007;118:115-22.

Anthrax lethal toxin paralyzes actin-based motility by blocking Hsp27 phosphorylation. During RL, Gibson BG, Li W, Bishai EA, Sidhu GS, Landry J, Southwick FS. EMBO J. 2007 May 2;26(9):2240-50.

A CapG gain-of-function mutant reveals critical structural and functional determinants for actin filament severing. Zhang Y, Vorobiev SM, Gibson BG, Hao B, Sidhu GS, Mishra VS, Yarmola EG, Bubb MR, Almo SC, Southwick FS. EMBO J. 2006 Oct 4;25(19):4458-67.

Phosphoinositide 3-kinase is required for intracellular Listeria monocytogenes actin-based motility and filopod formation. Sidhu G, Li W, Laryngakis N, Bishai E, Balla T, Southwick F. J Biol Chem. 2005 Mar 25;280(12):11379-86.

Anthrax lethal toxin paralyzes neutrophil actin-based motility. During RL, Li W, Hao B, Koenig JM, Stephens DS, Quinn CP, Southwick FS. J Infect Dis. 2005 Sep 1;192(5):837-45.

CapG(-/-) mice have specific host defense defects that render them more susceptible than CapG(+/+) mice to Listeria monocytogenes infection but not to Salmonella enterica serovar Typhimurium infection. Parikh SS, Litherland SA, Clare-Salzler MJ, Li W, Gulig PA, Southwick FS. Infect Immun. 2003 Nov;71(11):6582-90.

Chauncey, KM, MC.Lopez, G Sidhu1, S E Szarowicz, HV Baker,, C Quinn and FS Southwick. Bacillus anthracis Lethal Toxin Induces Broad Transcriptional Responses in Human Peripheral Monocytes. BMC Immunology 13: 33-58, 2012

Bharwani, AM., Harris, GC, and Southwick, FS. A Business School Perspective on Medical Interprofessional Rounds: Transforming Rounding Groups into Rounding Teams. Acad. Med. 87: 1768-1771, 2012

Bishai, EA, Sidhu, GS, Li, W, Dhillon, J, Bohil, AB, Cheney, RE, Hartwig, JH and Southwick, FS. Myosin-X facilitates Shigella-induced membrane protrusions and cell-to-cell spread. Cellular Micro. 15:353-67, 2013

Southwick, F, Lewis, M, Treloar, D, Cherabuddi, K, Radhakrishnan, N, Leverence,, R, Han, X. and Cottler, L Applying Athletic Principles to Medical Rounds to Improve Teaching and Patient Care. Acad. Med. 89: July 2014

Please click here for a list of Dr. Southwick’s industry relationships.